Anti Alzheimer uses the scientifically validated GENUS method — a precise combination of acoustic (4 Hz) and optical (40 Hz) stimulation to support the brain's glymphatic clearance system and activate microglia. For its functionality, the application needs the ability to set the display refresh rate to 120 Hz!!!
Your brain generates toxic metabolic waste every second. The glymphatic system — the brain's unique waste-clearance network — removes it during sleep. The key lies in the right frequency.
During deep non-REM sleep, the interstitial space between neurons expands by up to 60%. Cerebrospinal fluid (CSF) flows through the tissue, flushing out amyloid-beta and tau proteins — the key biomarkers of Alzheimer's disease.
Fultz et al. (Science, 2019) demonstrated a direct synchronisation: neurons go quiet → blood flows out → CSF pulses inward. The app reinforces this rhythm using 4 Hz amplitude modulation of sound.
MIT research (Prof. Li-Huei Tsai, Nature 2016/2019) showed that 40 Hz visual and acoustic stimulation activates microglia — the brain's immune cells — which physically engulf amyloid plaques.
Combined light and sound 40 Hz stimulation produces a synergistic effect. Studies in mouse models showed amyloid plaque reduction of up to 63%, with neuroprotection persisting even after stimulation ended.
The volume of space between neurons increases by this much during deep sleep, enabling CSF to flow through and flush waste.
The boost in slow-wave activity (SWA) achieved in older adults during synchronised acoustic stimulation.
Decrease in amyloid burden in the prefrontal cortex of a mouse model of Alzheimer's disease with combined GENUS 40 Hz stimulation.
Anti Alzheimer offers two scientifically grounded protocols that can be combined for maximum effect.
Enhancing slow-wave activity for more efficient glymphatic clearance and memory consolidation.
4 Hz · Theta / DeltaActivating the brain's immune cells for active removal of amyloid plaques using 40 Hz stimulation.
40 Hz · GammaSimultaneous optical and acoustic 40 Hz stimulation creates multisensory entrainment. Research from MIT and MGH confirms that the combination of light and sound produces a clearly synergistic effect on amyloid plaque reduction and microglial activation compared with either modality alone. The app supports seamless switching between protocols as well as their concurrent use.
Pulsatile clearance and AQP4: Glymphatic flow is driven by arterial pulsation and vasomotion — the rhythmic contraction of blood vessels. The key to efficiency is the Aquaporin-4 (AQP4) protein on astrocyte endfeet surrounding cerebral blood vessels. Fragmented sleep leads to depolarisation of these channels and reduced flushing efficacy.
CSF–EEG synchronisation: Fultz et al. (Science 2019) demonstrated a 1:1 correlation between slow-wave amplitude and the volume of CSF entering the brain. Increasing SWA by 25% strongly predicts a proportionally more vigorous mechanical flush of the parenchyma.
GENUS and microglia: Iaccarino et al. (Nature 2016) and Murdock et al. (Nature 2024) showed that rhythmic 40 Hz stimulation activates microglia via endogenous gamma oscillations in the hippocampus and visual cortex, increasing phagocytosis of amyloid-beta and tau proteins.
Technical implementation of 40 Hz on a 120 Hz display: Directly rendering 40 Hz on a 120 Hz display is non-trivial (120/40 = 3 frames per cycle, yet each state requires 1.5 frames — physically impossible without dithering). The app uses an ABB AAB BAA BBA sequence; thanks to visual persistence (integration time), the brain smooths the asymmetry and perceives a clean 40 Hz oscillation.
Anti Alzheimer is grounded exclusively in peer-reviewed studies published in leading scientific journals.
Iliff JJ, Wang M, Liao Y et al. defined the glymphatic system as the functional waste-clearance system of the CNS, dependent on AQP4 channels and sleep.
GlymphaticsXie L et al. (Nedergaard lab) demonstrated that glymphatic flushing occurs primarily during sleep and that sleep deprivation immediately elevates amyloid-beta levels in CSF.
Sleep · AmyloidIaccarino HF et al. (MIT, Tsai lab) showed that 40 Hz light stimulation activates microglia in the hippocampus and reduces amyloid burden in a mouse model of Alzheimer's disease.
GENUS · 40 HzPapalambros NA et al. (Northwestern Univ.) demonstrated a 25–30% increase in SWA amplitude and improved memory consolidation with rhythmic acoustic stimulation synchronised to slow waves.
SWA · MemoryFultz NE et al. established a direct link between slow-wave amplitude and the volume of CSF entering the brain — the mechanistic basis for SWA enhancement therapies.
CSF · EEGNedergaard M & Goldman SA presented a unified model in which glymphatic dysfunction is the shared terminal pathway leading to neurodegenerative disease.
Dementia · PreventionImportant Notice: Anti Alzheimer is a digital prevention and wellness tool. It is not a medical device within the meaning of EU MDR 2017/745 and is not intended for the diagnosis, treatment, or prevention of any specific disease. The research cited comes from peer-reviewed publications; findings from animal models may not translate directly to humans. Large-scale clinical GENUS trials are ongoing (MIT, MGH; results expected 2026). Individuals with epilepsy, photosensitivity, or serious neurological conditions should consult a physician before use.